EFFECTIVENESS OF DIAGNOSTICS AND TREATMENT OF MULTIDRUG RESISTANT FORM OF TUBERCULOSIS

EFFECTIVENESS OF DIAGNOSTICS AND TREATMENT OF MULTIDRUG RESISTANT FORM OF TUBERCULOSIS

Zakirova K.A., Mahmudova P.U., Mahmudova R.U., Sultanova S.K.

EFFECTIVENESS OF DIAGNOSTICS AND TREATMENT OF MULTIDRUG RESISTANT FORM OF TUBERCULOSIS

Department of Phthisiopulmonology of the State Educational Establishment «Institute of Postgraduate Education in Health Sphere of Republic of Tajikistan»

Aim. Examine the effectiveness of diagnostic and effectiveness of treatment of multidrug-resistant tuberculosis in Re­public of Tajikistan.

Materials and methods. Performed analysis of an officially published statistics on drug-resistant tuberculosis from 2008 to 2012, of the National Center for Tuberculosis Control in the framework of the “Program to protect the population from tuber­culosis in Republic of Tajikistan for 2010-2015”.

Results. Drug resistance to antituberculosis drugs (anti-TB drugs) started to define with the support of WHO. In 2008 in Dushanbe and Rudaki district (population 324 thousand. man — 13,9% of the countrys population). Cultures studied in supranational laboratory in Gauting (Germany). The first study on drug resistance was conducted in 2008-2009 to the main anti-TB drugs. Multidrug resistance was 16.8% among newly diagnosed patients, including previously treated — 61%. The second study — a test to determine drug susceptibility (DST) — carried out in 2010-2011: cases of MDR-TB were 13% and 53,6%, respectively (a decrease among new cases 3.8% among the patients treated early — on 7,4%).

Conclusion. Obtained results indicate a qualitative improvement of indicators of effectiveness of treatment of patients with MDR-TB in the republic — from 53% to 58,4%, mortality rate decreased from 14,2% to 11,3%.

Key words: efficiency, diagnostics, treatment of drug-resistant forms of tuberculosis

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