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    THE IMPACT OF INDIRECT ELECTROCHEMICAL OXIDATION THE TOXICITY OF BLOOD IN PATIENTS IN THE TERMINAL PHASE OF PERITONITIS, DUE TO PANCREONECROSIS

    THE IMPACT OF INDIRECT ELECTROCHEMICAL OXIDATION THE TOXICITY OF BLOOD IN PATIENTS IN THE TERMINAL PHASE OF PERITONITIS, DUE TO PANCREONECROSIS

    Dostieva Z.A., Shumilina O.V., Muradov A.M., Hamrokulov A.A.

    The department of efferent medicine and intensive therapy TIPGPMP

    In 15 patients with pancreonecrosis complicated by the terminal phase of peritonitis, we estimated the effect of indirect electrochemical blood oxidation on the state of the detoxification function of the lungs by intravenous 0,06% solution of sodium hypochlorite. To study the detoxification function of the lungs compared the blood of the right ventricle of the heart and arterial blood from radiotherapy or femoral artery, taken simultaneously. Study was carried out after 1 and 4-6 h after infusions of the mentioned solution. If, prior to the infusion of sodium hypochlorite concentration of urea and creatinine in the blood drains were reliably higher than in streams to the light respectively by 20,9% and 12,9%, for 1 hour, these figures are reduced to the respective indicators of 18,2% and 7,6%, and after 6 hours of light to see themselves their detoxifying that points to the restoration of detoxification functions of the body. The results obtained showed that sodium hypochlorite solution is a powerful oxidant toxic blood components, primarily amphiphilic, hydrophilic and hydrophobic metabolites, are in low – small and medium molecular fractions, as well as lipid structures of cell membranes due to changes in their perme­ability and mode of operation. The use of a solution in the first 4-6 hours causes significant improvement detoxification function of the lungs and its recovery depending on the stage of the infringement.

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    Information about the authors:

    Muradov Alisher Mukhtarovich – the chair of department of efferent medicine and intensive therapy TIPGPMP, Dr. med. sci., professor; Tel: (+992) 900730110; e-mail: alishermuradov@ mail.ru

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