FEATURES OF PSYCHOSOMATIC MANIFESTATIONS AT ACUTE MYELOBLASTIC LEUKEMIA
FEATURES OF PSYCHOSOMATIC MANIFESTATIONS AT ACUTE MYELOBLASTIC LEUKEMIA
Mustafokulova N.I., Ganieva M.P., Ahunova N.T., Boronov J.B.
FEATURES OF PSYCHOSOMATIC MANIFESTATIONS AT ACUTE MYELOBLASTIC LEUKEMIA
Department of Internal Diseases №3 of Tajik State Medical University named after Abuali-ibn-Sino Department of Therapy with a Course of Gerontology of State Educational Establishment «Institute of Postgraduate Education in Health Sphere of Republic of Tajikistan»
Aim. Rate features of psychosomatic manifestations and quality of life of patients at acute myeloblastic leukemia.
Materials and methods. The study protocol includes prospective and perspective (from 2009 to 2014 years) observation of 140 patients with acute and chronic myeloblastic leukemia. The average age is 35,9±0,7 years. Male — 62 (45,9%), wom¬en — 78 (54,1%). Of which 70 patients amounted to 1 group with acute myeloleukemia, 2 group — 70 patients with chronic myeloleukemia. Both groups the determination of the level of psycho-emotional sphere with the help of ospital Anxiety and Depression Scale (HADS) was conducted. To assess the quality of life and efficiency of rehabilitation activities in patients with acute leukemia the use of SF-36 questionnaire was provided. The calculation was made according to special transformation of scales. Evaluation was performed on a 100-point system.
Results. Study of patients by anxiety and depression scale (HADS) was performed on the second or third day admission to the hospital and again two weeks after the therapy. The test results on the scale of HADS led to the conclusion of reliable differencesthe of level of anxiety in both groups: 1 group with high levels of anxiety included 6 patients (12 points) and 2 group at high risk of anxiety included 12 patients. Subclinically expressed depression on a scale of HADS detected in 8 patients. In patients with chronic myeloblastic leukemia subclinically expressed depression detected in 13 patients (8 points). At a combination of anxiety and depression on a scale of HADS in 1 group more number of patients — 39 (14/14), in the second group — 31 patients (14/13). Subclinically expressed stage in 1 group observed in 3 (10,9), in 2 group — in 10 (19/9 points), which is high in both groups. It is established that the quality of life of patients with acute and chronic myeloleukemia, determined using the SF-36 questionnaire significantly reduced. After 4 weeks of using assigned sedative therapy showed a significant (p <0,05) improvement in the quality of life of patients with acute and chronic myeloleukemia.
Conclusion. Stress and psychological disorders in patients with acute myeloid leukemia accompanied by high levels of a combination of anxiety and depression, clinically significant in 55,7%. Psychophysiological violations identified in patients with chronic myeloid leukemia in 44,3% of cases. In order to improve the quality of treatment at depressive states, recommended using of sedative drugs, tranquilizers, at high performance — with using of programs of antidepressants that increase the educational level of patients: holding the conversation, lectures and autogenous training.
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