MODERN ASPECTS OF ANTIPHOSPHOLIPID SYNDROME. INFLUENCE OF EXOGENOUS RISK FACTORS OF THROMBOSIS IN THE ANTIPHOSPHOLIPID SYNDROME.

MODERN ASPECTS OF ANTIPHOSPHOLIPID SYNDROME. INFLUENCE OF EXOGENOUS RISK FACTORS OF THROMBOSIS IN THE ANTIPHOSPHOLIPID SYNDROME.

Holova Z.U., Ahunova N.T., Sharipov H.S.

MODERN ASPECTS OF ANTIPHOSPHOLIPID SYNDROME. INFLUENCE OF EXOGENOUS RISK FACTORS OF THROMBOSIS IN THE ANTIPHOSPHOLIPID SYNDROME.

Department of Therapy of the State Educational Establishment «Institute of Postgraduate Education in Health Sphere of Republic of Tajikistan»

Aim.Studying of the relationship between thrombosis, their recurrence and exogenous risk factors in APS.

Materials and methods. The study included 80 patients (63 women and 17 men). They were divided into 3 groups: 1-22 patients with systemic lupus erythematosus (SLE), 2-30 patients with SLE and APS, 3-28 patients with primary APS. All patients were interviewed by a specially designed map Fiscal registrar (FR). Also assessed the impact on development of thrombosis treatment with corticosteroids and cyclophosphan.

Results. As the prevalence of exogenous risk factors (abuse of fat and fried food, coffee, alcohol) group of patients were not significantly different. The connection of these FR with a history of thrombosis was not found. Physical inactivity was the most characteristic of patients with APS (23,1% compared with 10,7% of patients with SLE without APS), a greater number of patients with APS are marked the excessive body weight (38%). In patients with primary APS percentage of smokers was higher, however, the influence of smoking on the development of thrombosis was not revealed. The direct correlation of the presence of occlusion with the intake of corticosteroids and cyclophosphamide method dopplergram vessels. By the method of vascular dopplerography the direct connection between the presence of occlusion with the intake of corticosteroids and cyclophosphamide was found.

Conclusion. The risk factors of venous thrombosis in patients with APS (primary and secondary) are obesity and glucocorticosteroids.

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