Abstract
Summary
Presented clinical case with an 8-month history of red lichen planus of oral cavity, resistant to standard therapy. A
course of PDT with Photodithazine® 0.5% gel (0.1 ml/cm², exposure 10–15 min) was performed, followed by 660±10 nm
laser irradiation (100 mW/cm², 9 J/cm², 90 s/field, 30% overlap), five sessions per week, in addition to ongoing basic
therapy. Pain (VAS), quality of life (OHIP-14), lesion area (morphometry), and laboratory markers (IL-6, CD8α) were
evaluated. By the 14th day, the ulcer area had decreased by ≈ 60%; by the 35th day, complete epithelization was
achieved. Pain decreased from 6 to 0 VAS points, and OHIP-14 decreased from 24 to 6.
Five-session PDT with chlorin e6 demonstrated high clinical efficacy and a favorable safety profile for erosive and
ulcerative lichen planus.
course of PDT with Photodithazine® 0.5% gel (0.1 ml/cm², exposure 10–15 min) was performed, followed by 660±10 nm
laser irradiation (100 mW/cm², 9 J/cm², 90 s/field, 30% overlap), five sessions per week, in addition to ongoing basic
therapy. Pain (VAS), quality of life (OHIP-14), lesion area (morphometry), and laboratory markers (IL-6, CD8α) were
evaluated. By the 14th day, the ulcer area had decreased by ≈ 60%; by the 35th day, complete epithelization was
achieved. Pain decreased from 6 to 0 VAS points, and OHIP-14 decreased from 24 to 6.
Five-session PDT with chlorin e6 demonstrated high clinical efficacy and a favorable safety profile for erosive and
ulcerative lichen planus.
Keywords
lichen planus
oral cavity
photodynamic therapy
chlorin e6
erosive–ulcerative form
epithelialization.
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