Abstract

Objective
Construction and evaluation of the effectiveness of
a therapeutic model using carbon dioxide in periodontal
diseases.
Materials and Methods
60 laboratory rats of the Wistar
line served as biological material for the study. The
experimental animals were surgically modeled into
a periodontitis clinic, after which some of the animals
underwent carboxytherapy, leaving the other part of the
animals without specif-ic treatment. Carboxytherapy
was performed in two modes. After removing the
animals from the experiment, micro-preparations of the
damaged jaw were made and the histological picture
was compared.
Results
The use of injectable carboxytherapy,
accompanied by an increase in carbon dioxide
levels, contributed to the regeneration of damaged
periodontal tissues and the elimination of the ac-idotic
state. At the end of the study, bone destruction with a
tendency to sponging was detected in the animals of
the control group. fibroblast-like cells were found in
the interosseous spaces. We con-sidered, among other
things, the approximation of its structure to a spongy
substance as evidence of the destruction of the alveolar
bone. In contrast to the picture in the control group, the
histological parameters of animals exposed to CO2 did
not differ from the norm
Conclusion
An experimental study has shown that
carbon dioxide injections can be used to improve tissue
trophism and stimulate compensatory processes in the
treatment of inflammatory per-iodontal diseases

Keywords

periodontitis carboxytherapy carbon dioxide experiment modeling therapy.

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References

  1. Kolsanov A.V., Trunin D.A., Khaikin M.B [et al.] Vozmozhnosti ispolzovaniya karbokciterapii pri zabolevaniyakh parodonta: dokklinicheskoe eksperimentalnoe issledovanie [Use of carboxy-therapy in the treatment of periodontal diseases: a preclinical experimental study]. Kybanskiy nauchniy meditsinskiy vestnik – Kubani scientific medical herald, 2024, N 31(1), pp. 27-38.
  2. Svizhevskaya Ju.A. Karbokciterapiya [Carboxytherapy]. Flagman nauki - Flag officer of the science, 2024, N 5(16), pp. 226-230.
  3. Serikova A.A., Iordanishvili A.K., Sjldatova L.N. Effektivnost metoda invazivnoy karbokciterapii pri lechenii bolevoy disfunkcii bisochno-nizhnechelyustnogo sustava [Invasive carboxytherapy effecctiveness in the treatment of painful temporomandibular joint dysfunction]. Parodontologija- Parodontology, 2022, N 27(4), pp. 52-357.
  4. Ahramiyanpour N, Shafie’ei M, Sarvipour N. [et al.] Carboxytherapy in dermatology: A systematic review. J Cosmet Dermatol., 2022, Vol. 21, N 5, pp. 1874-1894. [https://doi.org/10.1111/jocd.14834](https://doi.org/10.1111/jocd.14834)
  5. Bagherani N., Smoller B.R., Tavoosidana G. [et al.]. An overview of the role of carboxytherapy in dermatology. J Cosmet Dermatol., 2023, Vol. 22, N 9, pp. 2399-2407. [https://doi.org/10.1111/jocd.15741](https://doi.org/10.1111/jocd.15741)
  6. Brochado T.M., de Carvalho Schweich L., Di Pietro Simões N. [et al.]. Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency. Int. Wound J., 2019, Vol. 16, N 2, pp. 316-324. [https://doi.org/10.1111/iwj.13031](https://doi.org/10.1111/iwj.13031)
  7. Prazeres J., Lima A., Ribeiro G. The effect of carbon dioxide therapy on skin wound healing. Biomedicine, 2025, Vol. 18, N 13(1), pp. 228. [https://doi.org/10.3390/biomedicines13010228](https://doi.org/10.3390/biomedicines13010228)
  8. Krumpuzos G., Aurora G., Kassir M. [et al.]. Carboxytherapy in dermatology. Clinical dermatology, 2022, Vol. 40, N 3, pp. 305-309. [https://doi.org/10.1016/j.clindermatol.2021.08.020](https://doi.org/10.1016/j.clindermatol.2021.08.020)
  9. Sakai Yu., Miwa M., Oe K. [et al.]. A new system for percutaneous administration of carbon dioxide, causing an «artificial Bohr effect» in the human body. PLoS One, 2011, N 6(9), pp. 24-37. [https://doi.org/10.1371/journal.pone.0024137](https://doi.org/10.1371/journal.pone.0024137)